Professor Mehta currently serves as deputy medical director (research), distinguished professor in Clinical Innovation in Ophthalmology, Singapore National Eye Centre (SNEC), and academic vice-chair (research) with the SingHealth Duke-NUS Ophthalmology and Visual Science Academic Clinical Programme. He holds concurrent appointments as executive director of the Singapore Eye Research Institute (SERI) and also heads the SERI Tissue Engineering and Cell Therapy Research Group. He also serves as senior consultant and former head of the Cornea and External Eye Disease Department at SNEC. He is also a tenured Professor at the Duke-NUS Medical School.

He is a leading specialist in the world on corneal diseases and refractive surgical procedures. His research interests span across all aspects of corneal external disease and refractive surgery, with corneal transplantation research as the key focus. He has also driven various research projects, many of which have produced breakthroughs and patents with high translational potential.

Professor Mehta has authored over 520 peer-reviewed papers in acclaimed international journals and authored over 24 book chapters. He has earned a high H-index of 73 (with over 20,500 citations) and has published in NEJM, Lancet, Lancet Resp Medicine, Nature Biomedical Engineering, Nature Review Disease Primers, PRER, Ophthalmology, and others. He has filed 24 patents from his research work, of which six have been commercialized and licensed to companies. As a leader of one of the top research programs at SERI, he has received several competitive research grants, achieving over $15 million as principal investigator. He is currently ranked number 1 in the world for expertise in cornea and number 2 for refractive surgery on expertscape.com. He has given over 350 invited lectures, 19 named lectures; and
serves the editorial board of several ophthalmic and visual sciences journals.

He has received many international awards including Nakajima Award (Asia Pacific Academy for Ophthalmology, 2013), Senior Achievement Award (American Academy of Ophthalmology, 2017 and 2023), Doug Coster Lecture (Australia and New Zealand Cornea Society, 2018), Charles Tilett Lecture (Fuchs Society, USA, 2020), Casebeer Award (International Society of Refractive Surgery, AAO, 2020), the Charles McGhee Medal (BSRS, Oxford UK, 2023), APAO Senior Achievement Award 2023, and the ACE
Award (APACRS, 2023).

Professor Mehta is a committed educator, teaching various local and international courses. He also supervises and mentors: Transition awards (NMRC), foundation grant (Singhealth), NIG (NMRC), junior clinicians, fellows (over 30 local and international), researchers (Ph.D. and MS.c students), and undergraduate students.